Improving medication- and patient safety by improving in-hospital prescribing

Period 2019-2024

Prescribing errors (PEs) in the in-hospital setting, resulting from inappropriately prescribed medication, can cause adverse drug events (ADEs) resulting in patient harm, prolonged hospital stay and hospital readmission. Over the past decades, this challenge remains a worldwide topic of awareness resulting in the development of several intervention strategies. Despite, numbers are not declining. Development of such strategies requires insight and understanding of factors influencing in-hospital prescribing process. In this thesis we will explore a multifaceted in-hospital intervention by a multidisciplinary team, consisting of stakeholders in the in-hospital prescribing process – medical doctors and pharmacists. We hypothesize that this thesis will provide insight at which points in the chain of prescribing PEs occur, what their root causes are, what risk factors are for PEs and what the effect is of such a multidisciplinary in-hospital team.

PhD-student: Rashudy Mahomedradja,
Promotor: Prof. dr. M.A. van Agtmael
Co-promotors: Dr. J. Tichelaar & Dr. K. Sigaloff

Optimizing transitional pharmacotherapeutic car

Period 2022-2026

Polypharmacy (the use of > 5 medications daily) poses an ongoing healthcare challenge, as it is associated with negative outcomes such as adverse drug events, lower quality of life and mortality. These risks are especially elevated for the frail and old, leading to high numbers of drug related admissions (DRAs) and unplanned emergency department visits. Unfortunately, up till now, despite multiple efforts to decrease drug related harm with different intervention strategies, the number of drug related admissions has not decreased. In the LIMONCELLO-study, we will study an optimised transitional pharmacotherapeutic care intervention, with extra focus on multidisciplinary and patient-centered care, in a patient population that has an elevated risk for drug related hospital admissions due to risk factors such as old age and multimorbidity. We hypothesise that transitional multidisciplinary pharmacotherapeutic care (TMPC) is superior in preventing drug related readmissions (DRreAs) compared to usual care.

PhD-student: Eline Engelen,
Promotor: Prof. dr. M.A. van Agtmael
Co-promotors: Dr. W. Knol & S. Wuyts